A rapid, efficient, cost effective procedure has been developed for the synthesis
of 2-butyl-5-chloro-3H-imidazole-4-carboxaldehyde. Preparation of methyl pentanimidate was accomplished
in just 12 hours, followed by a sequence of reactions without isolation and purification
of the formed intermediates. The final compound was purified by simple acid-base treatment
to get a product with 99.9% HPLC purity.
imidazole - imidates - Vilsmeier reagents - nitrile - tetrazole
